Flumazenil for Acute Poisoning?

Is it safe to give flumazenil to acutely poisoned patients, some with unknown poisoning. The authors of this retrospective study suggest it may. Of 904 patients only 13 seized and 1 died after flumazenil administration.

I think one need to have very very good reasons before take the risk to patients in reversing a safe poisoning when observation and supportive care will suffice. Not to mention the agitation...

Reference: A poison center's ten-year experience with flumazenil administration to acutely poisoned adults. Kreshak AA, et al. J Emerg Med. 2012 Oct;43(4):677-82. doi: 10.1016/j.jemermed.2012.01.059. Epub 2012 Jul 4.

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