Is it safe to give flumazenil to acutely poisoned patients, some with unknown poisoning. The authors of this retrospective study suggest it may. Of 904 patients only 13 seized and 1 died after flumazenil administration.
I think one need to have very very good reasons before take the risk to patients in reversing a safe poisoning when observation and supportive care will suffice. Not to mention the agitation...
Reference: A poison center's ten-year experience with flumazenil administration to acutely poisoned adults. Kreshak AA, et al. J Emerg Med. 2012 Oct;43(4):677-82. doi: 10.1016/j.jemermed.2012.01.059. Epub 2012 Jul 4.
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